LABVOLUTION 2017

•••4••• Innovationen Unprecedented insights “Pharmacoscopy” – the next-generation microscopy A novel microscopy method al- lows unprecedented insights into the spatial organization and direct interactions of immune cells within blood and other liquid mul- ti-lineage tissues. The assay, called “Pharmacoscopy”, developed and patented by scientists from CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, is able to determine immunomodulatory properties of drugs within large libraries on im- mune cells in high resolution and high throughput. Introduced in Nature Chemical Bio- logy, Pharmacoscopy enables new possibilities for drug discovery, par- ticularly in cancer immunotherapy, personalized medicine, and the research on signaling pathways of the immune system. By combining state-of-the-art high-throughput fluorescent microscopy with single cell image analysis and novel anal- ysis algorithms, Pharmacoscopy provides a powerful solution. De- veloped by a group of scientists at CeMM led by Director Giulio Super- ti-Furga and tested in collaboration with the Medical University of Vi- enna, Pharmacoscopy can quantify the overall spatial patterning and direct interactions of immune cells within blood with unprecedented speed and accuracy. Combined single cell resolution and fully automated platform con- trol, Pharmacoscopy can test large drug libraries, as available in the PLACEBO (Platform Austria for Chemical Biology) laboratory, for compounds with immunomodula- tory potential. “We found that ten per cent of all approved drugs test- ed influence the immune system in someway –much of whichwas not known, ” states Gregory Vladi- mer, one of the co-first authors of the study. With this method, the scientists identified Crizotinib, an FDA ap- proved drug for non-small cell lung cancer, to have a previously unknown immunomodulatory po- tential: “With Pharmacoscopy, we could track how Crizotinib enables cytotoxic T-cells to attack cancer cells,” explains Berend Snijder, the other co-first author. “Pharmacoscopy is not only a new and powerful tool for drug discov- ery; it can also be implemented in basic research by visualizing the ef- fects of signaling molecules on the immune system,” says Giulio Super- ti-Furga, senior author of the study and scientific director of CeMM. Innovationsforum Optogenetik: Licht als Werkzeug im Labor Die Nutzung von Licht als Werkzeug für die Labor- branche steht am 16. Mai imMittelpunkt des Biotech- nica Forums. Prof. Dr. Alexander Heisterkamp vom Laser Zentrum Hannover e. V. referiert dabei um 10.30 Uhr zum Thema „Innovationsforum Optogene- tik – Technologien und Potentiale“. Ob Photosynthe- se oder Sehsinn – in der Natur steuert das Licht eine Vielfalt von fundamentalen Prozessen. Dieses Wissen wird inzwischen in vielen technischen Bereichen ge- nutzt. Vorgestellt werden die Optogenetik, eine neu- artige Basistechnologie bestehend aus Optik und Gentechnik. Ziel ist es, diese für Fortschritte in der Biomedizin, Robotik, Biotechnologie und weiteren Anwendungsbereichen einzusetzen. Das Biotechnica Forum ist in Halle 20 am Stand D30 zu finden. ChipScope soll Blick ins Innere lebender Zellen erlauben Im EU-Forschungsprojekt ChipScope wollen For- scher ein neues, extrem kleines Lichtmikroskop entwickeln. Damit soll das Innere lebender Zellen in Echtzeit beobachtet wer- den können. Sieben Insti- tute in fünf europäischen Ländern beteiligen sich über die nächsten vier Jahre an diesem technolo- gisch anspruchsvollen Projekt, teilt die Techni- sche Universität Braun- schweig mit. Die zukünfti- gen Einsatzmöglichkeiten des neu zu entwickelnden und nur wenige Millimeter großenMikroskops sind äu- ßerst vielfältig. Die Projektpartner haben sich eine An- wendung herausgegriffen. ZumProjektende sollen an- hand medizinischer Labor untersuchungen Zellveränderungen veranschaulicht werden, die bei idiopathischer Lungenfibrose, kurz IPF, auftreten. Galliumnitrid-LED-Chip mit optobiomedizi- nischen chemischen Sensoren Foto: Hutomo Suryo Wasisto / TU Braunschweig Gregory Vladimer, Nikolaus Krall, Berend Snijder and Giulio Superti-Furga (from left to right) next to the Pharmacoscopy high-throughput microscope Photo: Wolfgang Däuble / CeMM Anzeige LEMAN INSTRUMENTS is a leading Euro- pean company, specialized in standard products, OEMs and in custom designed realisations in- volving High Purity H2, N2 Zero Air, com- bined solutions for FIDs, GCs, purge Air generators, CH4 & CO2 scrubbers, N2 and multigas for LCMS with high level of commu- nications involving Ethernet, USB, RS 485 and possibility of AK protocol integration . One of Leman Instruments’ newest innova- tions is its combined technology gas genera- tor, the GC STATION 60LC . The single unit incorporates an inboard compressor and is a concept unlike any other currently offered in the marketplace. 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